Objective In young adults, sugar-sweetened beverage (SSB) intake is associated with dental caries, which in turn is a major contributor to tooth loss. The independent role of SSB intake on tooth loss, however, has not been well-described. This cross-sectional study examined associations between tooth loss and SSB intake among U.S. young adults. Methods The outcome was number of permanent teeth lost because of dental caries or periodontal disease (0, 1–5, ≥6 teeth). Data from the 2012 Behavioral Risk Factor Surveillance System were used. The 22,526 adults aged 18-39 years completed the Sugar Drink Module. The exposure variable was daily frequency of SSB intake. We used multinomial logistic regression to examine the adjusted associations between tooth loss and daily SSB consumption (0, >0 to <1, 1–2, >2 times/day). Results Approximately, 26% of young adults reported losing at least one permanent tooth. Tooth loss was positively associated with SSB intake frequency; the odds of losing 1–5 teeth were higher among adults drinking SSBs >0–<1 times/day (OR = 1.44, 95%CI = 1.16–1.79), 1–2 times/day (OR = 1.58, 95%CI = 1.25–1.99), and >2 times/day (OR = 1.97, 95%CI = 1.51–2.58) than non-SSB consumers. The odds of losing ≥6 teeth were higher among adults drinking SSBs 1–2 times/day (OR = 2.20, 95%CI = 1.15–4.22) and >2 times/day (OR = 2.81, 95%CI = 1.37–5.76) than non-SSB consumers. Conclusions Frequency of SSB consumption was positively associated with tooth loss among young adults even when the average SSB intake was less than one time per day. This study suggests that efforts to reduce SSB intake among young adults may help to decrease the risk of tooth loss.