Transgender people, i.e., those whose gender identity differs from the sex they were assigned at birth, have been shown to be disproportionately affected by HIV. Transgender women have an estimated global HIV prevalence of 19.1%, a rate consistently higher than almost any other key population . In the USA, the vast majority of transgender individuals affected are people of color with a reported HIV prevalence among African-American transgender women of 44.1% . Over half of all new HIV diagnoses in transgender people occur in African-Americans . Few data exist for HIV prevalence among transgender men, however studies frequently report increased HIV risk behaviors, including condomless anal sex and sexually transmitted infections [2,4–7] in this population. The recent estimate of 3.2% in transgender men far exceeds the US general population prevalence . The elevated HIV prevalence in transgender populations is due to a combination of psychosocial and structural factors, such as high rates of societal stigma and discrimination leading to unemployment, poverty, psychological stress, mood disorders, and reduced access to health care including HIV prevention interventions .